HYDROXY-CHLOROQUINE ZINC & Z-PAK: Quackery or Solid Science?

AUGUST 5 UPDATE: Last week, I quoted with approval Yale epidemiologist Dr. Harvey Risch’s review of reports on the efficacy of HCQ against early stage Covid-19. This link will take you to his faculty colleague’s rebuttal. Their bottom line: “Let us be clear: we are unanimous in our desire to see the development of therapies to treat COVID-19 and to prevent the transmission or acquisition of SARS-CoV-2. If HCQ was shown to be effective, even among subgroups of patients with COVID-19 in ongoing high-quality trials, we would join our colleagues in promoting access to it for all who need it. However, the evidence thus far has been unambiguous in refuting the premise that HCQ is a potentially effective early therapy for COVID-19.”

Over fourteen million people watched a Facebook Live press conference in front of the U.S. Supreme Court building by the group, America’s Frontline Doctors, on Monday. By Tuesday, all social media platforms had pulled it, and fact-checking sites everywhere were dismissing it as quackery. Even their website was gone. Why? Because the doctors at the conference were calling—loudly in one case—for Hydroxychloroquine, Zinc, and Azithromycin (Z-Pak) to be made available to the public as the standard of care for early symptomatic Covid-19, and as prophylaxis against catching the disease.

I thought their arguments were sound and their experience as primary care physicians and ER docs credible. That’s why I was discouraged to find sources quoting Nigerian native Dr. Stella Emmanuel—the most passionate and combative of the group—as saying some rather outlandish things about other topics. I liked Dr. Emmanuel’s sincerity, but her comments in other fields—if accurately reported—diminished the credibility of the group.

Still, the absolute silencing, eerily similar to twentieth-century Soviet erasure of opposition voices from the public record, disturbed me. Dismissing them as “doctors with a conservative agenda” does nothing to address the facts. Do these medicines work, or not? That’s all that matters.

I am not a conspiracy theorist. But people on the political left are just as passionate about their convictions as I am about mine. And sometimes, passion and cynicism about the other side blind us to facts.

That is what I think is happening with Hydroxychloroquine, Zinc, and Z-Pak. But I still wasn’t prepared to write about it until I read Dr. Harvey A. Risch’s Newsweek article from July 23. Dr. Risch, a Yale epidemiologist, has the academic credentials and publishing record that America’s Frontline Doctors, despite their clinical experience, lack.

A few of his most cogent comments from the article:

“I am usually accustomed to advocating for positions within the mainstream of medicine, so have been flummoxed to find that, in the midst of a crisis, I am fighting for a treatment that the data fully support but which, for reasons having nothing to do with a correct understanding of the science, has been pushed to the sidelines. As a result, tens of thousands of patients with COVID-19 are dying unnecessarily.”

“I am referring, of course, to the medication hydroxychloroquine. When this inexpensive oral medication is given very early in the course of illness, before the virus has had time to multiply beyond control, it has shown to be highly effective, especially when given in combination with the antibiotics azithromycin or doxycycline and the nutritional supplement zinc.”

Risch goes on to mention doctors he knows who’ve risked their careers to prescribe these medications for their patients, governments that have reversed course on banning the drug, and mistakes in the FDA’s reporting on the risks associated with its use. Like Dr. Emmanuel and Dr. Gold of America’s Frontline Doctors, he recognizes that patient health is more important than politics.

Do we?